PGxO: A very lite ontology to reconcile pharmacogenomic knowledge units

SNP-Converter: An Ontology-Based Solution to Reconcile Heterogeneous SNP Descriptions for Pharmacogenomic Studies

Suggested Ontology for Pharmacogenomics (SO-Pharm): Modular Construction and Preliminary Testing

Pharmacogenomics studies the involvement of interindividual variations in DNA sequence into different drug responses (especially adverse drug reactions). Knowledge Discovery in Databases (KDD) process is a means for discovering new pharmacogenomic knowledge units in biological databases. However data complexity makes it necessary to guide the KDD process by representation of domain knowledge. T...

Combining statistical and logical inference for ontology alignment

In recent years, ontologies have proved a very attractive medium for storing domain knowledge in a variety of organizations; a few example domains are medicine and genetics. The rapid evolution of representation standards has led to the creation of distinct ontology bases in overlapping domains, making it paramount for large systems to reconcile ontological data from multiple sources. A large b...

Pharmacogenomic knowledge representation, reasoning and genome-based clinical decision support based on OWL 2 DL ontologies

BACKGROUND Every year, hundreds of thousands of patients experience treatment failure or adverse drug reactions (ADRs), many of which could be prevented by pharmacogenomic testing. However, the primary knowledge needed for clinical pharmacogenomics is currently dispersed over disparate data structures and captured in unstructured or semi-structured formalizations. This is a source of potential ...

On the Update of Description Logic Ontologies at the Instance Level

We study the notion of update of an ontology expressed as a Description Logic knowledge base. Such a knowledge base is constituted by two components, called TBox and ABox. The former expresses general knowledge about the concepts and their relationships, whereas the latter describes the state of affairs regarding the instances of concepts. We investigate the case where the update affects only t...